Mass photometry is a label-free, single-molecule technique that measures the mass of biomolecules in solution with exceptional accuracy and sensitivity. By detecting the light scattered by individual molecules as they land on a glass surface, it enables the direct analysis of molecular mass, oligomeric states, and complex formation in real time. Mass photometry offers a rapid, non-destructive way to study proteins, nucleic acids, and biomolecular assemblies, making it a powerful tool for assessing sample purity, stoichiometry, and interactions under native conditions. Key applications include the analysis of AAV particles (distinguishing between empty and full capsids, assessing packaging efficiency, etc.) and the study of antibodies and their interaction.
This workshop is organised by Core Facility Biomolecular Interaction and Crystallography, in CEITEC part of Instruct-CZ, with collaboration of Refeyn and Specion.