Are you fascinated by how neuronal synapses assemble at the molecular level? Join our lab to explore synapse formation with cryo-EM/ET imaging in a supportive and ambitious research environment.
A 4-year PhD position is available in the research group of Dr. Dimphna Meijer at the Department of Bionanoscience, Delft University of Technology (TU Delft), the Netherlands.
The long-term goal of our research is to understand synapse assembly and disassembly at the molecular level, during health and disease. We address questions such as: What is the structural basis of synapse formation? What happens at the nanoscale in a diseased brain? Recently, we determined several cryo-EM structures of synaptic cell adhesion molecules that together reveal part of a molecular recognition code. In this project, you will take a bottom-up approach to study synapse assembly. You will work with minimal, well-controlled synaptic assemblies and characterize them using cryo-electron tomography (cryo-ET), and complementary light microscopy approaches.
Specific Objectives Are
You will be the scientific driver of the project and gradually grow towards independence as a researcher, while working closely with the PI and other group members. You will receive hands-on supervision and training in cryo-ET, structural biology and advanced microscopy.
The department offers state-of-the-art facilities, including high-end light and (cryo-)electron microscopes and advanced mammalian cell culture infrastructure.
Why join the Meijer lab?
You will join an international research group that values scientific rigor, open discussion and mutual support. As a PhD candidate, you will be closely supervised while being encouraged to develop your own ideas and scientific independence. The project combines fundamental questions with cutting-edge methods, offering excellent opportunities for personal and scientific growth. See also our group website.
Job Requirements
We are looking for a curious, motivated and collaborative researcher who is excited to work at the interface of structural biology and neuroscience.
You hold a M.Sc. degree in nanobiology, biochemistry/biophysics, structural biology, or a related field.
You have experience with electron microscopy or structural biology approaches, or a strong interest in learning these techniques.
Experience with cryo-EM or cryo-ET is a strong plus but not required.
You are fluent in English and enjoy working in an international research environment.
For more information and to apply, see here.
Application Deadline: 5 July 2026
