As a leading research institute of the French National Center for Scientific Research (CNRS) and of the University of Toulouse, the Institute of Pharmacology and Structural Biology (IPBS) conducts state-of- the-art research in cancer biology, immunology, microbiology, structural biology and biophysics. It is a world leader in the discovery, characterization, validation and exploitation of novel pathways and pharmacological targets in the fields of cancer, infection, and inflammation, by combining molecular and cellular biology approaches and in vivo experiments.
In order to reinforce its inspiring, collaborative and cutting-edge environment, the IPBS is seeking a talented group leader using/developing integrative structural biology and biophysical approaches to tackle biological questions that are of key interest to the institute, with priority on:
Microbiology and drug discovery
Structure-function relationship of proteins involved in bacterial virulence and drug resistance. Phenotypic, virtual and biophysical screening of chemical and fragment libraries. Structural and functional characterization of drug-target interactions.
Inflammation and Infection biology
Role of the microenvironment in inflammatory and infectious diseases; impact on treatment. Development, differentiation and migration of immune cells. Antimicrobial immunity and host-pathogen interactions.
Cancer microenvironment and biology
Implication and targeting of stromal components, matrices, metabolism and immune cells in tumor progression, including immuno-therapy. DNA repair and damage response (DDR); DDR-targeted drug discovery; tumor resistance or vulnerabilities to clastogenic agents or DDR modulation.
Outstanding candidates at early-career stage, are expected to develop competitive, independent research and meet the required criteria for successful application to national and international funding, including ATIP-Avenir, FRM, ANR program, ERC-StG or CoG, or equivalent installation grant, and to a tenured position at CNRS. Senior researchers holding a CNRS or University position are also welcome to apply. The IPBS upholds a commitment to affirmative action and equal opportunity.
Starting package: The successful candidate will be provided with a starting package including office and lab space for 5-6 people as well as technical staff support, seed funding, and mentoring to obtain a tenured position and installation grants. He/she will benefit from free access to on-site technological facilities (imaging, proteomics, structural biology, high throughput screening and animal facilities) and a collaborative and multinational scientific environment, in an ambiance fostering equality, diversity and inclusivity.
Applications (in English) should be sent before May 14, 2024 as a single file named LASTNAME_IPBS2024.pdf to recruit@ipbs.fr and should include (i) a cover letter, (ii) a CV with complete list of publications, (iii) 2-3 reference letters (iv) a summary of past achievements (2 pages) and (v) future research project (3 pages).
Tentative calendar
Mid-June: Preselection of candidates
Early-July: Interview of preselected candidates by the international selection committee
Mid-July: Outcome of the selection process
From September: Application for grants and tenured position
